China's Pesticide Intermediate Industry Overview

[Abstract]:
(I) Output in creases year by yearChina hasp roduced more than 800 varieties of pesticide intermediates, with a production volume of nearly 4.9 million tons.

  (I) Output increases year by year

  China has produced more than 800 varieties of pesticide intermediates, with a production volume of nearly 4.9 million tons. China's pesticide industry has established a relatively complete industrial system including the production of raw drugs, the preparation of intermediates, and the preparation of pharmaceuticals.

  With the development of new pesticides in the country, some special intermediates have been developed rapidly, such as fluorine-containing, cyano-containing, and heterocyclic intermediates, among which the pyrethroid intermediates such as chrysanthemic acid and dichlorine are more prominent. Chrysanthemic acid, butyric acid, ether aldehyde, allyl alcohol. Such intermediates can be produced domestically at present, and the production sites are currently mainly concentrated in Shanghai, Zhejiang, and Jiangsu. In addition, the technological transformation of some pesticide intermediates is also relatively active. The main achievements are: synthesis of pinacol by isopenene, methanol synthesis by methanol carbonyl, catalyzed synthesis of chloroacetic acid and diethoxy thiophosphoric acid by acetic anhydride. Acrylic chloride new technology, directional crystallization extraction of refined naphthalene, directional chlorination of dichlorobenzene production, phase transfer catalytic reaction, diketene synthesis of chloroacetyl chloride, catalytic hydrogenation to produce aromatic amine compounds. The pesticide intermediates produced in China during this period can basically meet the needs of the pesticide industry, but there are still some intermediates that still need to be imported, such as DV methyl chrysanthemate, dibromo chrysanthemic acid, o-cresol, m-cresol, o-benzene Phenol, furanol, pyridine and its salts, piperidine (hexahydropyridine), paraformaldehyde and the like. Among the imported products, some of them are produced domestically, but the quantity or quality cannot meet the production requirements; the other part is that domestic production is still not possible. In recent years, the import volume of pesticide intermediates in China is about 100 million U.S. dollars.

  In order to meet China's pesticide development, pesticide product structure adjustment requirements, and to shorten the gap with the foreign pesticide industry, pesticide intermediates will focus on the development of the following products: pesticide intermediates that cannot be produced in China, intermediates for high-toxicity pesticide replacement products, and Heterocyclic pesticide intermediates, fluorine-containing pesticide intermediates, and chiral pesticide intermediates.

  1. Heterocyclic-containing pesticide intermediates

  (1) Intermediates of organophosphorus insecticides containing heterocyclic rings, including intermediates of diazinon, chlorpyrifos, quinoline, chlorprophos, and chlorzophos. (2) Intermediates containing high-level insecticides containing heterocycles, including intermediates of imidacloprid, imidacloprid, fipronil, and chlorfenapyr. (3) Intermediates of highly effective fungicides containing heterocycles include quinoxalines and furazolidone intermediates. (4) Intermediates containing heterocyclic herbicides, including general sulfonylurea herbicide intermediates, intermediates of imidazolinone herbicide imazethapyr, imazaquin, and triclopyr, quinclorac , thiadiatum intermediates.

  2. Fluorine-containing pesticide intermediates

  In the search for ways to improve biological activity, fluorine is often used instead of hydrogen or chlorine. This kind of substitution can greatly improve the efficacy of pesticides. The introduction of fluorine atoms in the pyrethroid structure will increase the efficacy of pests and have a killing effect. Therefore, fluorine-containing pyrethroids have attracted attention. However, to prepare the most active compound it is necessary to select the fluoro-position of the molecule. Insertion of fluorine atoms plays a key role in biological activity, but fluorine-substituted hydrogen often reduces the activity. However, the most active compounds often contain fluorine atoms at certain positions in the molecular structure. At the same time, it is necessary to prepare highly active fluorine-containing compounds. There are fluorine-containing intermediates, so it is necessary to research and develop fluorine-containing intermediates.

  There are more than 50 manufacturers of fluorine-containing intermediates in China, mainly in Jiangsu, Zhejiang, Jiangxi, Anhui, and Liaoning provinces. There are quite a few varieties produced, but they mainly serve the pharmaceutical industry, but these production companies are small in size and variety. Single, the products are mainly exported to foreign countries, and there are not many manufacturers of pesticides and fluoride intermediates, mainly the corresponding production of fluorine-containing pesticide production plants. China's fluorinated pesticide intermediates must be actively developed. Enterprises with a certain economic scale should be established. Multi-functional production facilities should be established. Products with similar production processes should not only require technological innovation, but also improve the technological level, and must also pay attention to environmental protection issues and reduce " "Three wastes", saving energy and reducing consumption, gradually becoming large-scale and serialized, and interacting with the fluorine-containing intermediates required by the pharmaceutical industry, not only to meet exports, but also to ensure domestic demand, in order to make China's pesticide-containing fluorine intermediates flourish. development of.

  Pesticide intermediates are the basis for pesticide production. To form a pesticide intermediates industry in China, continuous technological innovations will enable China's pesticide intermediates to meet China's renewed pesticide production, and be able to outsource production or export, and production technologies can catch up with the world. Advanced level, product quality can reach the level of similar foreign products. The development of pesticide intermediates is fundamental, quality is the core, and technological innovation is the key.

  (B), profit is expected to increase

  The pesticide intermediates industry is facing an embarrassing situation in which the scale has been expanded and the overall profitability has declined. In the pesticide intermediates industry, although the overall level of profitability is high, it has been showing a steady downward trend since 2008, which is basically maintained at around 13%.

  The raw materials for the production of pesticide intermediates are mainly basic chemical raw materials, and their bargaining power is relatively low. The product has low added value. The current situation in China's pesticide intermediates industry with only a long period of time and no increase in profits is mainly due to the prominent problems in the industry such as a single product structure, low added value, and fierce competition among companies.

  At present, there are still large gaps between domestic companies producing intermediate products and foreign companies. First, domestic production companies are small in size and single in structure. There are only a handful of companies that can form economies of scale. This leads to the inability of the company's economic strength and its limited investment in product development. Second, the company's product structure convergence, low-end products, the added value is not high. At present, the low-level construction of domestic manufacturers is more serious. As a result, the production capacity of some products is excessive, and the operating rate is seriously insufficient. Companies compete for prices and economic efficiency declines.

  At present, China's production of pesticide intermediates varies in size. Most of them are pesticide companies. There are only dozens of large-scale state-owned or state-controlled enterprises. The industry is faced with problems such as resource reconfiguration and pressure on market competition. In addition, at present, pesticide intermediates in China are mostly bulky products with low added value, while most of the high value-added products such as fluorinated pesticide intermediates need to be imported.

  (III) Production Status of Pesticide Intermediates

  With the development of new pesticides in the country, some special intermediates have been developed rapidly, such as fluorine-containing, cyano-containing, and heterocyclic intermediates, among which the pyrethroid intermediates such as chrysanthemic acid and dichlorine are more prominent. Chrysanthemic acid, butyric acid, ether aldehyde, allyl alcohol. Such intermediates can be produced domestically at present, and the production sites are currently mainly concentrated in Shanghai, Zhejiang, and Jiangsu. In addition, the technological transformation of some pesticide intermediates is also relatively active. The main achievements are: synthesis of pinacol by isopenene, methanol synthesis by methanol carbonyl, catalyzed synthesis of chloroacetic acid and diethoxy thiophosphoric acid by acetic anhydride. Acrylic chloride new technology, directional crystallization extraction of refined naphthalene, directional chlorination of dichlorobenzene production, phase transfer catalytic reaction, diketene synthesis of chloroacetyl chloride, catalytic hydrogenation to produce aromatic amine compounds. The pesticide intermediates produced in China during this period can basically meet the needs of the pesticide industry, but there are still some intermediates that still need to be imported, such as DV methyl chrysanthemate, dibromo chrysanthemic acid, o-cresol, m-cresol, o-benzene Phenol, furanol, pyridine and its salts, piperidine (hexahydropyridine), paraformaldehyde and the like. Among the imported products, some of them are produced domestically, but the quantity or quality cannot meet the production requirements; the other part is that domestic production is still not possible. In recent years, the import volume of pesticide intermediates in China is about 100 million U.S. dollars.

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